L-Ascorbate-2-Phosphate

    • Product Name: L-Ascorbate-2-Phosphate
    • Chemical Name (IUPAC): Sodium (2R)-2-[(1S)-1,2-dihydroxyethyl]-4,5-dihydroxyfuran-3-one 2-(dihydrogen phosphate)
    • CAS No.: 38663-78-2
    • Chemical Formula: C6H7O9P
    • Form/Physical State: Powder
    • Factroy Site: Shuangfeng Industrial Park, Zichuan District, Zibo City, Shandong Province
    • Price Inquiry: sales7@bouling-chem.com
    • Manufacturer: Luwei Pharmaceutical Group Co., Ltd
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    Specifications

    HS Code

    154062

    Product Name L-Ascorbate-2-Phosphate
    Chemical Formula C6H7O9P
    Appearance White to off-white powder
    Solubility Soluble in water
    Storage Temperature 2-8°C
    Cas Number 6628-78-8
    Purity ≥98%
    Ph Range 6.0-7.5 (1% solution in water)
    Stability Stable under recommended storage conditions
    Synonyms L-Ascorbic acid 2-phosphate, Magnesium Ascorbyl Phosphate (MAP) salt
    Application Cell culture additive, antioxidant
    Melting Point Decomposes above 200°C
    Hazard Class Non-hazardous for transport
    Ec Number 229-407-8

    As an accredited L-Ascorbate-2-Phosphate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Application of L-Ascorbate-2-Phosphate

    Purity 98%: L-Ascorbate-2-Phosphate with purity 98% is used in cell culture media formulation, where it promotes enhanced collagen synthesis and cell proliferation.

    Stability pH 7.0: L-Ascorbate-2-Phosphate with stability at pH 7.0 is used in tissue engineering scaffolds, where it supports long-term antioxidant protection during cell differentiation.

    Water solubility >10 g/L: L-Ascorbate-2-Phosphate with water solubility >10 g/L is used in injectable formulations, where it ensures rapid dissolution and consistent bioavailability.

    Molecular weight 322.19 Da: L-Ascorbate-2-Phosphate with molecular weight 322.19 Da is used in pharmaceutical research, where it allows precise dosing and reproducible pharmacokinetic studies.

    Thermal stability up to 60°C: L-Ascorbate-2-Phosphate with thermal stability up to 60°C is used in high-temperature bioprocess applications, where it maintains antioxidant capacity throughout processing.

    Particle size <50 µm: L-Ascorbate-2-Phosphate with particle size <50 µm is used in topical dermatological preparations, where it achieves enhanced skin penetration and controlled delivery.

    Endotoxin level <0.1 EU/mg: L-Ascorbate-2-Phosphate with endotoxin level <0.1 EU/mg is used in stem cell therapy media, where it minimizes immunogenic reactions and supports cell viability.

    Oxidative stability >48 hours: L-Ascorbate-2-Phosphate with oxidative stability >48 hours is used in dietary supplement premixes, where it preserves vitamin C activity during storage.

    Assay ≥99%: L-Ascorbate-2-Phosphate with assay ≥99% is used in nutraceutical production, where it guarantees consistency in active ingredient content and product efficacy.

    Heavy metals <10 ppm: L-Ascorbate-2-Phosphate with heavy metals <10 ppm is used in cosmetic formulations, where it ensures safety for use in sensitive skin applications.

    Packing & Storage
    Packing White screw-cap bottle labeled "L-Ascorbate-2-Phosphate, 25g," featuring hazard symbols, chemical information, and batch number for laboratory use.
    Container Loading (20′ FCL) L-Ascorbate-2-Phosphate is shipped in 20′ FCLs, typically packed in 25kg fiber drums on pallets, optimizing bulk transport.
    Shipping L-Ascorbate-2-Phosphate is shipped in tightly sealed containers to protect it from moisture and light. During transit, it is kept at 2-8°C and handled as a non-hazardous chemical. Standard documentation and labeling are provided for safe delivery, with expedited shipping available to maintain product stability and quality.
    Storage L-Ascorbate-2-Phosphate should be stored tightly sealed in a cool, dry place, away from light and moisture. Ideally, keep it at -20°C for long-term stability. Protect the container from air and humidity to prevent degradation. Avoid exposure to oxidizing agents. For best results, dissolve only before use and minimize repeated freeze-thaw cycles to maintain its chemical integrity.
    Shelf Life L-Ascorbate-2-Phosphate has a shelf life of 2-3 years when stored tightly sealed at 2-8°C, protected from light.
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    More Introduction

    L-Ascorbate-2-Phosphate: Our Approach and Focus on Quality

    Real-world Applications and What Sets Us Apart

    The market for vitamins and nutritional enhancers has grown rapidly over the past decade, but the need for a more stable, bioavailable source of vitamin C continues to shape research and development in food, feed, and skin care industries. L-Ascorbate-2-Phosphate answers this call. As the primary manufacturer, we base all improvements and decisions on the needs voiced by formulation chemists, nutritionists, and quality managers at the user end. That feedback has driven us to put stability and purity first, because real production environments rarely allow for error or compromise in raw materials.

    Standard ascorbic acid loses potency during processing. Heat, oxygen, and light speed up degradation, which hits both product performance and shelf-life. In seeking a solution decades ago, L-Ascorbate-2-Phosphate became the focus of global attention. Its phosphate group protects the fragile vitamin C structure, dramatically slowing oxidation and breakdown. Product designers in formulated feeds, aquaculture, and cosmeceuticals quickly noticed improved results—higher vitamin retention rates, longer shelf stability, and enhanced bioavailability in target applications. That clear advantage holds true even today, with stricter compliance demands and consumer expectations at an all-time high.

    Product Model and Specifications

    Through years of iterative refinement, our L-Ascorbate-2-Phosphate reaches exceptional purity and stability benchmarks. The manufacturing process uses proprietary enzymatic techniques and advanced purification, fully within the factory, limiting source variance. By maintaining production from synthesis to packing under one roof, we retain control over every step.

    Our most popular model, L-Ascorbate-2-Monophosphate (MAP) 35% feed grade, satisfies both mainstream and challenging high-mix application lines. Rigorous in-house analytical testing guarantees phosphate content, ascorbate activity, and ultra-low heavy metal residues. Moisture content control prevents premature hydrolysis and degradation, helping factories reduce caking and dust problems during blending. These product specifics did not happen by chance: each reflects input from users facing scaling headaches, temperature spikes in extrusion, and long transport times in humid regions.

    Production batches reach consistency by multi-point in-process QC checks. From raw ingredient verification, to phosphate addition, to captured fines during drying, our factory runs on protocol and real-time monitoring. HPLC and UV assays confirm ascorbate content above threshold values, and all product leaves in tamper-evident packaging. Every drum or bag can be traced backward through its lot code. This level of traceability becomes nonnegotiable when our product enters the nutrition chain—for animals or people—and informs the standards we uphold in every lot.

    Usage in Industry Settings

    Animal nutrition operators know the cost of poor vitamin retention. In easy-to-digest feeds, standard vitamin C disappears before it can confer benefits. During pelleting, crumbling, or extrusion, temperature and moisture push ascorbic acid content below label targets. That hits both compliance risk and the animals’ health outcomes. L-Ascorbate-2-Phosphate solves this problem at the source, offering a resilient, slow-releasing version of vitamin C that survives heat and pressure better.

    In aquaculture, stress-related disease flare-ups can drain profits overnight. Effective vitamin C fortification supports immune function in fish and shrimp. Failures in vitamin delivery show up as poor growth or higher disease incidence. L-Ascorbate-2-Phosphate, optimized for water stability, avoids the rapid leaching seen in regular ascorbic acid, helping nutritionists reduce over-formulation and wastage.

    Cosmetic formulators face different but related issues. Water-based skin care products often suffer from vitamin C degradation, which can generate discoloration and lose claimed activity within weeks. This limits both consumer trust and shelf appeal. Using L-Ascorbate-2-Phosphate, cosmetic creators get a stable and bioavailable form that activates as soon as skin phosphatases release the vitamin. This single attribute underpins the growing adoption in serums and lotions worldwide, especially in climates subject to wide temperature swings during storage and transport.

    Differentiating L-Ascorbate-2-Phosphate: A Manufacturer’s Viewpoint

    A frequent question we field concerns the distinctions among ‘ascorbate phosphates.’ Several brands push D-isoascorbate or calcium ascorbate, presenting them as interchangeable. Yet, from the standpoint of actual synthesis and real-world usage, key differences emerge. L-Ascorbate-2-Phosphate hits the sweet spot of readily restored vitamin C bioactivity and high process resistance. It does not “flood” the system with free vitamin immediately, nor does it rely on pH conditions as strictly as esters or salts do. These seemingly small points matter whenever feed mixers or cosmetic labs run tightly controlled processes that cannot tolerate vitamin loss or delayed conversion.

    Strict quality checks differentiate industrial-grade and feed-grade ascorbate-2-phosphate from food or cosmetic grades. Feed-use versions may allow for certain excipients or anti-caking agents, while our cosmetic grade never carries these. End-users in pharmaceuticals, especially those working on oral dosage, require particle size refinement and minimal excipient profiles, as cGMP rules demand granular traceability and process repeatability.

    Compared with sodium ascorbate or ascorbyl palmitate, our L-Ascorbate-2-Phosphate forms remain stable over extended shelf lives in powder, premix, or suspension. This lets end-users warehouse stock for months without losses that can throw off blending calculations or face recalls. Direct comparisons in pilot-line trials often uncover the hidden losses associated with cheaper, less robust C sources. That’s why many nutrition manufacturers switched to our product after dealing with batch rejections and quality drift caused by non-phosphorylated forms.

    Quality and Compliance from a Manufacturing Perspective

    Maintaining consistent phosphate substitution in every batch demands discipline across the production floor. Deviations in raw material pH, water quality, or temperatures have immediate downstream consequences on ascorbate yield. Our process uses only food-grade reagents and deionized water, documented at every stage. Process chemists, not just operators, oversee synthesis and work closely with QC teams to ensure batch-to-batch reproducibility. Over the years, we’ve found that investing more in operator training and independent instrument calibration pays back through minimized complaint rates and repeat orders from satisfied partners.

    International audit demands keep rising. Whether for FAMI-QS, ISO, or region-specific requirements set by authorities in North America, Europe, or East Asia, each finished lot stands on its documented history. Regulatory inspectors visiting our plant look for real, not cosmetic, adherence to SOPs—especially in segregated storage, in-line cleaning, and changeover documentation. We host regular outside audits and always welcome partners to observe production first-hand. This transparency builds confidence and lasting business relationships where consistency counts for everything. When formulators and nutrition experts visit to see blending, sampling, and loading firsthand, they walk away clear on how each control measure supports their downstream quality guarantees.

    Adulteration crises in the broader vitamin industry have hurt both trust and margins in recent years. Large traders and smaller blenders sometimes cut corners by relabeling or blending off-spec material to pad profit margins. We counter this through in-plant marking, closed-loop documentation, and regular audits of packaging and shipping teams. Barcode and lot tracking help distributors and mixers trace material back to the precise production moment. This practical transparency, far from being a regulatory box-tick, allows us to pinpoint sources of defects or mislabeling before shipments exit our gates. Purchasers and partner labs appreciate the reduction in surprises and nonconformities.

    Supporting Fact-Based Development in End-Products

    Innovation cannot happen without robust, reliable ingredients. In the early days of vitamin C fortification, end users rarely bothered about stability across months of transit or high-temperature extrusion. Now, every lost percent during mixing or storage raises red flags for QA and regulatory affairs. Our role as a manufacturer goes beyond simple supply. We regularly support downstream partners with stability studies under accelerated and real-world conditions. These studies not only verify stability claims in actual feeds, aquaculture diets, or human supplements; they also guide formulation improvement and prevent costly reformulations or failed launches.

    Food and feed nutritionists frequently ask for data on ascorbate retention in their unique matrices and under harsh processing situations. By working together, we compile a large set of use-case-specific benchmarks. These allow feed millers to optimize C content without over-supplementing, reducing unnecessary cost and ingredient waste. For aquaculture, rapid leaching can waste vitamin investment within minutes; our studies show significantly reduced water-soluble losses using L-Ascorbate-2-Phosphate. In skin care, where product color and smell often signal vitamin degradation, chemists value the preserved ascorbate profile, which holds true under daylight or artificial lighting for extended periods. Instead of marketing hyperbole, we let the test results inform customer decisions.

    Manufacturing Intensification and Responsible Practice

    Production at scale introduces risks for cross-contamination, batch drift, or accidental substitution. As the manufacturer, we built redundancy into raw material checks, batch data review, and finished product isolation. Before any product exits for blending or packing, dual verification occurs—one manual, one automated. Investing in properly trained quality stewards and continuous operator education reduces the likelihood of errors made under line pressure or during equipment maintenance.

    Efficiency also means waste reduction. By tuning our process and recycling non-conforming or off-spec intermediates, scrap volume remains minimal. Hazardous waste streams, such as spent filtration media and wash water, undergo neutralization and regulated disposal. This environmental responsibility supports both regulatory compliance and social license to operate. Local stakeholders, including neighboring businesses and authorities, participate in regular reviews of our waste handling and raw material sourcing—a practice that pays dividends in risk management, productivity, and community trust.

    Recent years brought new pressures: demand surges during health scares, constraints in chemical supply lines, and energy price hikes that ripple through every plant system. Tackling these as a unified team, we invested in energy-saving dryers, waste heat recapture, and short-lot flexibility. Production planners collaborate with sales on realistic forecasts that minimize overproduction and prevent inferior storage conditions. Rather than pushing excess batches out of the plant, we prioritize flexibility and adaptive scheduling, so that each lot receives careful screening and only meets market once it passes post-blending QC.

    On Working Closely with End Users

    Our largest end-user groups, from multinational feed integrators to niche cosmetic labs, engage our technical support up front—not just at point of sale. Technical teams routinely visit customer sites to observe product handling, verify compatibility with other micronutrients, and train operators in best practices for hydration and dispersion. These site visits often uncover bottlenecks—excessive powder lumping, incompatible micro-dosing equipment, or temperature spikes that hit vitamin recovery. By understanding these realities firsthand, we refine support materials and suggest countermeasures, ensuring L-Ascorbate-2-Phosphate delivers on its core promise: protected, active vitamin C, available where and when it is most needed.

    Partner feedback often leads to real improvements, not just cosmetic changes. One feed partner running high-speed extruders flagged unusual caking during summer months. Working together, we tweaked particle size distribution and increased anti-caking measures for the next batch. In another case, cosmetic formulators reported off-odors in vitamin C serums in humid climates. By auditing storage and blending sequences, we identified specific process points needing extra stabilization. Neither improvement would have emerged from remote testing; both required eyes and experience at work sites. This two-way process helps ensure that benefits seen in technical datasheets translate to predictable, reliable results under real-world conditions.

    Pushing for Continuous Improvement

    No manufacturer operates without setbacks. Raw material disruptions, abnormal weather, or unforeseen market shifts require rapid response and steady focus. In 2022, input phosphate pricing whipsawed in a matter of weeks, creating uncertainty. Rather than push price hikes, we relied on long-term supplier relations, in-plant stocks, and batch scheduling that balanced production and customer demand. Transparent communication kept downstream partners informed and helped them plan feed and cosmetic runs in line with real supply. This long-term perspective ensures no batch gets rushed out untested, and major partners always receive both the product and documentation required for downstream compliance.

    Automation has grown across the plant over recent years, but experienced operators remain at the core of our production. Human judgment prevents errors that a sensor or timer cannot foresee. Blending and packing benefit as much from trained hands as from digital tracking. Cross-functional teams review every major product upgrade, and any deviation triggers both root-cause analysis and proactive remedial training. This approach ensures each batch of L-Ascorbate-2-Phosphate supports the high standards our users expect, and keeps us focused on practical benefit—not just production volume or nominal compliance.

    Conclusion: Meeting Today’s Demands with Proven Solutions

    L-Ascorbate-2-Phosphate stands as a practical response to the limitations found in earlier vitamin C forms. Manufacturing insights guide every improvement and control—from traceability and compliance, through technical support, to ongoing stability research. Each bottle, drum, or bag connects years of industry input, scientific progress, and relentless attention to detail. Our teams remain committed to the disciplines learned through daily plant management and close cooperation with partners. This direct link between manufacturing expertise and end-user innovation keeps L-Ascorbate-2-Phosphate at the center of trusted nutrition and cosmetic solutions worldwide.