| Names | |
|---|---|
| Preferred IUPAC name | (2R)-2-[(1S)-1,2-dihydroxyethyl]-4,5-dihydroxy-2H-furan-3-one 2-phosphate |
| Other names | AA2P Ascorbate-2-phosphate L-Ascorbic acid 2-phosphate Vitamin C phosphate L-Ascorbate-2-monophosphate L-AA2P |
| Pronunciation | /ɛl æsˈkɔːr.beɪt tuː fəˈsfeɪt/ |
| Identifiers | |
| CAS Number | 64186-27-6 |
| Beilstein Reference | 3569556 |
| ChEBI | CHEBI:59699 |
| ChEMBL | CHEMBL1234092 |
| ChemSpider | 16214172 |
| DrugBank | DB11363 |
| ECHA InfoCard | 03e14b667a15-41cb-b773-b6bffdbf753d |
| EC Number | 1.1.1.317 |
| Gmelin Reference | 87806 |
| KEGG | C00745 |
| MeSH | D015995 |
| PubChem CID | 11148780 |
| RTECS number | AS8050000 |
| UNII | 1E91O462IS |
| UN number | Not regulated |
| CompTox Dashboard (EPA) | DTXSID5028708 |
| Properties | |
| Chemical formula | C6H7O9P |
| Molar mass | 322.19 g/mol |
| Appearance | White to off-white crystalline powder |
| Odor | Odorless |
| Density | 1.374 g/cm³ |
| Solubility in water | Soluble in water |
| log P | -3.2 |
| Acidity (pKa) | 2.8 |
| Basicity (pKb) | 12.28 |
| Refractive index (nD) | 1.420 |
| Viscosity | Viscous liquid |
| Dipole moment | 5.5 D |
| Thermochemistry | |
| Std molar entropy (S⦵298) | 302.8 J·mol⁻¹·K⁻¹ |
| Pharmacology | |
| ATC code | A11GA |
| Hazards | |
| Main hazards | May cause respiratory irritation. May cause eye irritation. May cause skin irritation. |
| GHS labelling | GHS02, GHS07 |
| Pictograms | GHS07 |
| Signal word | Warning |
| Hazard statements | H319: Causes serious eye irritation. |
| Precautionary statements | P261, P264, P271, P272, P273, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, P362+P364, P501 |
| NFPA 704 (fire diamond) | Health: 1, Flammability: 1, Instability: 0, Special: - |
| Lethal dose or concentration | LD50 Oral Rat > 5000 mg/kg |
| LD50 (median dose) | LD50 (oral, rat): > 5000 mg/kg |
| NIOSH | Not Listed |
| PEL (Permissible) | PEL (Permissible Exposure Limit) for L-Ascorbate-2-Phosphate: Not established. |
| REL (Recommended) | 50 µg/mL |
| Related compounds | |
| Related compounds | Ascorbic acid Ascorbyl palmitate Dehydroascorbic acid Sodium ascorbate Magnesium ascorbyl phosphate |
| Category | Industrial Commentary |
|---|---|
| Product Name & IUPAC Name |
Product Name: L-Ascorbate-2-Phosphate IUPAC Name: [(2R)-2-[(1S)-1,2-dihydroxyethyl]-4,5-dihydroxyfuran-3-yl]methyl dihydrogen phosphate In routine production, the naming distinction clarifies the compound's biological activity and phosphate stabilization over standard ascorbic acid. Different grades might list regional variations in IUPAC nomenclature; naming accuracy supports regulatory documentation and facilitates customs classification. |
| Chemical Formula |
Molecular Formula: C6H9O9P Formula assignment aligns directly with production route choice and raw material quality. Minor side-product formation varies with process parameters; formula consistency is tracked batch-to-batch as a QC release checkpoint, supported by NMR and mass balance quantification during downstream purification. |
| Synonyms & Trade Names |
Synonyms: L-Ascorbic acid 2-phosphate, Ascorbyl phosphate, Vitamin C phosphate Trade Names: Often developed brand-specifically according to customer segment or region. In manufacturing, synonym usage typically references grade utility, whether for cell culture, feed, or food fortification. Bulk shipments reference regulatory-accepted synonyms on documentation to ensure smooth cross-border logistics. |
| CAS Number |
66241-81-6 The CAS identification enables rapid match-up with global regulatory inventories. Batch history includes CAS-matched references in issuance of certificates; this identification prevents mix-ups in both internal finished-goods storage and customer-side receiving operations. |
| HS Code & Customs Classification |
HS Code: 2936.27 Customs Classification: Vitamin derivatives, specifically tailored for import/export under ascorbic acid derivatives. Selection of HS Code involves evaluating the active moiety and intended market destination. Different jurisdictions interpret customs sub-classifications based on use or presence of phosphate group, which can affect duty rates or import license requirements. The documentation always clarifies intended application and product form, aiding customs brokers in border clearance. |
Production routinely delivers L-Ascorbate-2-Phosphate as a white to off-white solid, available both as a fine crystalline powder and as granules depending on grade and compaction requirements. Odor remains not pronounced; particulate size range is tailored as required by formulation partners. Melting point is rarely referenced in industrial documents, as thermal processing is avoided to limit decomposition; manufacturers do not boil or combust this material in standard handling.
Density is measured for bulk transport and formulation; values shift with granulation and moisture uptake. Direct surface exposure to humid air, light, or high temperature can alter surface characteristics and color — design of packaging addresses these reactivity risks.
Stability largely depends on careful control of storage environment and stabilizer inclusion if specified by the buyer. The phosphate modification enhances stability over native ascorbate, making it less sensitive to hydrolysis and oxidation under recommended conditions. Exposure to strong acids, bases, or metal ions may trigger degradation. Material is classed as sensitive to moisture and should not be dissolved until immediate use in solution is planned.
Solubility varies by grade and hydration state; most grades offered for cell culture, cosmetic, or nutritional uses dissolve in water at ambient or slightly elevated temperature with gentle stirring. Premixing with a small volume and gradual dilution minimizes undissolved residue and maintains pH integrity. Overheating or prolonged solution storage causes loss of activity, particularly in unbuffered or metal-exposed solutions.
Testing laboratories release multiple grades—analytical, food, cosmetic, and cell culture. Specification tables address appearance, purity (usually by HPLC or titration), water content (Karl Fischer), ash, and specific impurities. Finer distinctions, including particle size and heavy metal limits, are set as agreed with customers.
| Property | Range (Per Grade) | Test Method |
|---|---|---|
| Purity (L-Ascorbate-2-Phosphate) | Grade- and purpose-dependent | HPLC, titration |
| Loss on Drying | Specification by batch & region | Karl Fischer, gravimetric |
| Heavy Metals | Application-defined limits | AAS, ICP-OES |
| pH (1% Solution) | Grade-dependent | pH meter |
Final certificate incorporates customer contract requirements; additional limits (microbial, specific trace residues) apply for pharma or food use.
Main impurity risk comes from unreacted ascorbic acid, phosphate byproducts, and process intermediates. Each lot undergoes spot checks for known and potential contaminants. Any detected heavy metals, solvents, or organics must fall below regulatory and client-mandated levels.
In-process and finished goods control follow established internal SOPs, referencing pharmacopeial, food, or industry standards as relevant. Validation is process-specific and regularly requalified to meet or exceed regulatory standards.
Selection of raw materials starts with certified L-ascorbic acid and food/pharma-grade phosphate sources. Supplier audits address traceability, contamination history, and sustainability metrics, as finished product purity reflects input quality.
Manufacture often relies on phosphorylation of L-ascorbic acid using orthophosphate donors in controlled aqueous systems. Reaction conditions—temperature, catalyst load, and order of addition—significantly affect yield and downstream purification loads.
Key process controls address pH, order of reactant mixing, temperature profile, and exclusion of catalytic metals that could promote side-reactions. Impurities mainly arise from incomplete conversion or hydrolysis; purification typically involves filtration, recrystallization, or chromatography, selected by batch economics and target grade.
Batch consistency requires real-time analytical feedback and end-point testing responding to every major variability risk: input concentration, temperature deviation, and atmospheric exposure. Each lot is checked for color, pH, content, microbial status, and specific impurities prior to release.
Release hinges on full analytic panel clearance and documented batch record review. Where customer mandates differ from standard specifications, dual-certification practices apply.
L-Ascorbate-2-Phosphate resists oxidation better than ascorbic acid, serving as a more stable precursor for downstream redox processes or as a source of active vitamin C by enzymatic dephosphorylation in biological applications.
Product maintains structure under mild, neutral, aqueous conditions, but may degrade under strong acidic or basic environments, especially with the presence of transition metals. Catalyst selection (for any further modifications) carefully avoids species that accelerate ascorbate degradation.
Material offers potential as a controlled-release vitamin C in food and cosmetic matrices. Enzymatic dephosphorylation gives active ascorbate in situ. Industrial processes may use it for stable ascorbate input in multi-step syntheses, dependent on phosphate lability under process conditions.
Humidity and oxygen accelerate degradation to dehydroascorbate and other breakdown products. Storage calls for sealed, inert gas or vacuum-packed containers, in cool, dry, and light-protected environments. Warehouse temperatures and ambient humidity dictate optimal storage time, with cooler and drier storage extending shelf life.
High-density polyethylene or similar polymers are used to avoid leaching or peroxide formation; metal or glass vessels see limited use depending on exposure risk to reactive surfaces or ions.
Shelf life remains grade-dependent and must be supported by real-time and accelerated stability trial data. Degradation may lead to discoloration, clump formation, or reduced assayable content. Release testing prior to shipment ensures material within agreed validity window.
Classification details for L-Ascorbate-2-Phosphate depend on regulatory jurisdiction and batch impurity profile. The process aims at non-hazardous classification under typical finish but some grades, especially if dust is generated, may carry warnings for mild eye or respiratory irritation.
Standard precautionary measures: avoid inhalation, minimize exposure through engineered local exhaust, employ cleanroom or PPE procedures. Dust control avoids respiratory sensitization. Operators wash hands after use and before eating or drinking.
Product has low acute toxicity under tested routes (oral, dermal), aligning with its use in food and biological systems. Chronic exposure data are limited; safety reviews defer to authoritative risk assessments and region-specific monographs.
Routine handling under GMP or ISO procedures prioritizes personal safety through closed handling equipment and dust minimization. Area monitoring for airborne dust and surface contamination supports ongoing risk reviews as part of manufacturer EHS policy.
Current global production of L-Ascorbate-2-Phosphate, whether sodium or magnesium salt, remains concentrated in several established facilities. Capacity allocation swings in line with demand cycles in feed, cosmetic, and life science segments. Large-batch contract production takes priority due to plant changeover time and validated upstream synthesis runs. Inventory buildup seldom covers more than one quarter ahead due to product stability requirements and shelf-life management.
Lead time for standard L-Ascorbate-2-Phosphate output varies based on campaign scheduling. Routine lots for major clients hold at 3-4 weeks ex-works. Custom grades, or shifts in particle size or purity, can extend supply lead up to 6 weeks, driven by cleaning validation for multipurpose lines and parallel QC release. Minimum order quantities depend on package specification and grade; typically, industrial bulk exceeds 500 kg, custom / ultrafine types set higher MOQs to recover changeover costs.
Standard bulk formats use multi-layer polyethylene-lined fiber drums or reinforced PE bags inside rigid containers. Cosmetic- and food-grade supply mandates secondary containment and tamper-evident seals. For high-humidity or export conditions, vacuum-sealing or inert gas flushing is employed following analytical control of residual moisture and oxygen.
Shipments follow Incoterms agreed per client region, with DAP and FCA most frequent across Asia-Pacific and North America due to import control sensitivities. Payment terms reflect global raw material sourcing cycles and VC-minimized exposure. New clients face advance payment requirements scaling down to 30-60 day terms subject to credit review and contract scope.
Cost base tracks ascorbic acid, phosphorylating agent cost, purification media input, and batch processing energy. Ascorbic acid grades feed directly into plant batch economics, so disruption in fermentation intermediates and crop-derived glucose supply pushes base prices. Sudden spikes in phosphate ester reagents also influence cost, responding to broader chemical feedstock volatility such as phosphorus derivatives and caustic soda availability.
Price stratification aligns with grade, purity, and certification. Animal feed grade, with wider impurity and particle size tolerances, offers the lowest entry cost. Cosmetic and food applications, which demand higher assay specification, stricter trace metal limits, and validated allergen controls, command premiums based on incremental testing and reduced lot variability. Halal, Kosher, and GMP certification add stepwise surcharge by audit, segregation, and batch recall documentation. Packaging also skews pricing: small bags for laboratory use cost more per kg than tonnage containers to reflect handling and QA effort.
Upstream price swings reflect supply chain shocks impacting fermentation inputs for ascorbic acid, regulatory actions limiting phosphate reagent access, energy price growth, shipping disruptions, or local legislative burdens on chemical process byproducts. Industrial water use restrictions, rising compliance for effluent standards, and demands for green synthesis routes also filter through into landed cost for downstream processors.
Expansion in animal nutrition and personal care sectors in Asia-Pacific remains the largest single demand accelerator. The US and EU hold steady in terms of nutritional supplement and cosmeceutical use, but face more fluctuation driven by trade policy and regulatory change. China—leveraging vertical integration of ascorbic acid—remains both dominant supplier and price setter, but anti-dumping actions and increased import scrutiny in the EU and US occasionally distort traded volumes and spot price visibility.
| Economy | Demand Drivers | Supply Constraints/Risks |
|---|---|---|
| US | Nutritional grading, cosmetic regulation tightening, continued reliance on foreign supply | Tariff policy, long logistics chains, shifting customs requirements |
| EU | Stricter purity/purity requirements for foods and feed, environmental rules | REACH regulatory burden, increased audit frequency, local green process demand |
| JP | Reliable pharmaceutical and food additive demand | Preference for high-certified, low-metal trace input, cautious new supplier adoption |
| IN | Feed supplementation, growing domestic finished formulation use | Import-dependent on ascorbic acid & intermediates, rupee-dollar exchange volatility |
| CN | Integrated supply chain, exports drive major volumes | Government environmental controls, export permit bottlenecks during peak seasons |
Cost validation over 2021-2023 gives a base; early-2024 shows price volatility correlated to energy pricing, raw material input constraints in China, and changing demand in EU/US for certified feed and cosmetic grades. Forecasting suggests moderate upward price drift into 2026 attributed to sustained pressure on environmental compliance, phosphate reagent supply unpredictability, and increases in required certification. Internal forecasting factors in raw material indexation, third-party market analytics, and tracking of global freight cost benchmarks.
Increased dialogue around sustainable production processes has seen a surge in certifications and reporting requirements, especially from multinational nutrition and cosmetic conglomerates. Implementation of clean label initiatives in the EU influences raw material selection and plant audit frequency. Feed applications in Asia shifting toward higher certified grades also drive up demand complexity and batch traceability demands.
Tighter monitoring of phosphorus compounds and stricter effluent release thresholds in China and the EU alter the framework for plant permitting and ongoing environmental compliance. New export documentation requirements for feed- and food-grade volumes introduce further logistical lead time, especially for batch-certified product.
Manufacturing plants optimize batch campaign sequencing, improve in-process controls, and intensify outgoing batch testing to limit batch-to-batch variation and support audit readiness. Expanded digital traceability—batch origin to final container—facilitates rapid response in regulatory recall or inquiry contexts. Alternative sourcing on key reagents and stricter supplier qualification represent ongoing efforts to balance cost stability with compliance risk.
L-Ascorbate-2-Phosphate, produced through selective phosphorylation of L-ascorbic acid, carries functional and stability benefits distinct from ascorbic acid and sodium ascorbate. Year after year, we supply L-Ascorbate-2-Phosphate grades for a range of critical applications:
| Application | L-Ascorbate-2-Phosphate Grade | Relevant Parameters |
|---|---|---|
| Cell culture / bioprocessing | Cell culture grade Pharmaceutical grade (where applicable) |
Pyridoxal and heavy metal content, endotoxin level, sterility, particle characteristics, certificate of origin (TSE/BSE) |
| Animal feed | Feed grade | Assay (ascorbate equivalent), impurities (phosphates, metals), physical form, moisture, flow properties |
| Agriculture (tissue culture / foliar) | Agro grade Feed grade (with custom micronization for tissue culture) |
Grade-dependent purity, solubility, mesh size, trace contaminant profile |
| Cosmetics | Cosmetic grade Pharmaceutical/food grade (special purities) |
Aldehyde/ketone levels, color/clarity, peroxide value, microbial specifications, non-GMO and allergen status |
Production control focuses on those characteristics most sensitive to end use. In cell culture applications, manufacturers target ultralow impurities and endotoxins due to direct impact on cell proliferation and differentiation. Feed and agro grades emphasize cost-to-function optimization; purity targets balance nutritional requirement against operational constraints in high-volume blending and pelletizing. Cosmetic application batches are reviewed for appearance and oxidative stability to guarantee transparency in high-clarity water-based serums. Each segment requires traceability supporting regulatory audits and customer claims.
Establish target usage scenario and performance criteria. For producers in the cell culture industry, stress test requirements for endotoxin, low heavy metals, and batch-to-batch consistency. Feed compounders often prioritize reliable supply and assurance of declared assay.
Define the regulatory or customer standards for each target sector. Cell culture and bioprocess users should correlate with compendial or industrial guidelines, such as Ph. Eur., USP, or JP, where applicable. Feed and agro users refer to relevant national feed additive registries. Cosmetic formulators confirm compliance with INCI, allergen, and prohibited substance norms.
Decide on the acceptable limits for impurities. Ascorbate-2-phosphate grades differ substantially in residual inorganic phosphate, chloride, sulfate, and heavy metal profiles. Batch records should document analytical test results for the intended grade; refinement is based on contaminant sensitivity of the downstream process or animal species, not one-size-fits-all standards.
Validate whether bulk or specialty packaging supports operational needs. Manufacturers plan loading, storage, and rotation according to forecasted volume and shelf-life in real warehouse conditions. Lower-purity feed or agro grades align to high-volume, cost-driven applications, while cell culture and cosmetics have single-use or small-batch process logistics with higher per-unit value.
Sample evaluation by the customer’s QC or R&D team closes the selection process. This step screens for both specification fit and practical integration within the existing protocol or product formulation. Quality groups compare results from analytical checks—assay, contaminant profile, solubility, storage behavior, and shelf-life stability—and request additional process documents as needed. Final release criteria follow joint review of analytical, technical, and procurement requirements specific to customer and regulatory context.
During our manufacturing of L-Ascorbate-2-Phosphate, we maintain independent third-party certification of our overarching quality management system. Recognized system certifications form the foundation for documented traceability, deviation management, and production batch review. Auditors routinely evaluate process validation records, equipment cleaning regimes, and material trace logs as part of these standards. Specific certification scope covers both synthesis and purification operations typical for multi-purpose plant operations.
Our approach to product certifications focuses on end-application and market regulatory requirements. For food or pharma grades, relevant statements or compliance confirmations—such as certificates of analysis referencing pharmacopoeia monographs or alignment with global additive regulations—are issued according to lot and customer region. Veterinary and feed applications often require additional antibiotic residue declarations or specific qualifying statements supporting cross-border approvals. In some markets, Kosher and Halal certifications are provided once process and ingredient origin audits are completed.
Every batch of L-Ascorbate-2-Phosphate is shipped with a comprehensive analytical report listing the tested parameters and actual results for that specific lot. Testing regimens, parameter selection, and report format depend on whether the grade is technical, food, feed, or pharmaceutical. Extended impurity maps and stability data are available on request for customers with advanced quality control or regulatory compliance programs. Change notification and batch recall procedures are disclosed as part of supplier assessments or audits. Ongoing documentation includes product origin statements and supply chain transparency records.
The installed design throughput of the current L-Ascorbate-2-Phosphate plant allows calendarized production scheduling, accommodating both multi-tonne campaigns and smaller, customer-specific batch requests. Experience with both long-standing key accounts and new project clients informs our stock planning and advanced booking approach. Business teams cooperate across sales, quality, and logistics functions to enable annual contract locking, rolling order placements, or rapid spot-market fulfillment according to buyer risk appetite and inventory models.
Core process units for phosphate esterification, downstream neutralization, and multi-stage filtration are designed for rigorous, campaign-based operation. Main raw materials—ascorbic acid and phosphate salts—are dual-sourced to mitigate single-point-of-failure risk. Consistency of supply links directly to both equipment maintenance standards and logistics coordination, especially with critical reagents, packaging, or delivery routes subject to regional externalities. Batch campaign structure allows for quick adjustment to changing market signals without quality tradeoff, provided enough lead time for upstream adjustments.
Prospective buyers initiate sample requests by specifying application type and required regulatory documentation. Application screening ensures the correct product grade and documentation package match the buyer’s technical and compliance needs. Typical sample volumes align with downstream pilot trials and lab-scale qualification protocols. Expedited internal review of material hold-release decisions streamlines dispatch, while remaining responsive to customer change-requests during the evaluation phase. Advice on sample storage, analytical method compatibility, and test report interpretation is available through technical service channels.
Contractual flexibility is anchored in segmented pricing by monthly, quarterly, or annual volume bands. Minimum order quantities for L-Ascorbate-2-Phosphate shipments reflect both grade and packaging format as well as production scheduling realities. For customers facing fluctuating demand profiles, buffer stock pool arrangements or safety stock at bonded warehouses can be explored. For development-stage customers, regular conference calls and milestone-linked supply planning enable responsive scaling as the project progresses. Early technical engagement between formulation teams and our production technologists assists in troubleshooting atypical specification or product adaptation requirements.
Current industrial research on L-Ascorbate-2-Phosphate (AAP) focuses on stability enhancement, purity optimization, and cost-effective synthesis. In plant cell culture and animal feed, end users demand grades with low environmental contaminant residues and high UV stability. Research continues on improving resistance to hydrolytic degradation during incorporation in water-based formulations, as degradation directly impacts shelf-life and downstream application consistency. Multi-stage crystallization, advanced filtration, and specific precursor sourcing remain active topics in pilot and production-scale studies.
Prominent growth appears in sectors such as aquaculture, animal nutrition, and high-end cosmetics. End users in fish and shrimp farming require phosphate-stabilized vitamin C to avoid rapid oxidative loss typical of unprotected ascorbates. Demand is shifting towards products tailored for microencapsulation and slow-release feed premixes. In dermaceuticals, interest centers around compatibility with multi-phase cream matrices and photo-stability following air exposure.
Maintaining active content throughout aggressive sterilization and pelleting processes drives ongoing process controls. Technicians report that impurities, including residual free phosphate and unconverted ascorbate, can originate from both upstream raw material variability and side-reactions during phosphoesterification. Scale-up routinely uncovers new impurity profiles not observed at laboratory scale. The main breakthrough includes improvements in pH control and online monitoring during esterification, which lower unwanted hydrolysis. Process-specific challenges occur when switching between chemical and enzymatic routes; such decisions affect impurity spectra and dictate the stringency of downstream purification. Release criteria are tailored according to customer-specific antioxidant assay requirements in feed or cosmetic bases.
Projected growth in the next three to five years rests on both expanding animal nutrition regulations and continued development of plant-based cell culture technology. Global supply is influenced by raw material costs for ascorbic acid, which track with fermentation yields and precursor pricing. Regional regulatory harmonization, especially in Asia-Pacific and Europe, will determine market accessibility in food and feed segments. Product differentiation by grade purity and tailored functional performance drives new contract types and customer qualification processes, especially as bulk and niche demands diverge.
The trend moves towards lower-energy processes and waste minimization in the main esterification step. Movement from batch to semi-continuous or fully continuous operations hinges on both plant infrastructure and final product requirements. Efforts center on integrating in-line QbD (Quality by Design) monitoring, which allows for earlier impurity rejection and tighter spec release. Manufacturers now frequently partner directly with end-users to map product modifications to changing process or regulatory needs, rather than relying only on internal product development pipelines.
Production routes adopting solvent minimization and closed-cycle phosphate recovery generate interest among purchasing and sustainability teams. Specific sustainability metrics relate to waste phosphate management, water use, and the ability to document biobased origin of raw ascorbate. The sector faces ongoing challenges complying with upcoming regional environmental reporting and green labeling for food-grade and cosmetic customers. Continuous reduction of process residues, tracking original feedstock sources, and implementing renewable energy in drying and evaporation stages form the basis of recent environmental audits and customer site visits.
Direct access to production chemists and process engineers allows customers to resolve raw material compatibility, blending protocols, and specification inquiries. Guidance often includes side-by-side review of typical impurity profiles for each batch, based on grade and manufacturing route. Site audits and remote troubleshooting allow for technical discussion beyond standard product certificates.
Support teams collaborate with formulators on optimizing AAP incorporation in aqueous or lipid phases, including advice on pH adjustment, agitation regimes, and order of ingredient addition. Feed millers and cosmetic blenders benefit from shared pilot-lot data on storage stability, thermal resistance, and particle dispersibility—each property linked specifically to customer product grade and application method. Feedback from technical trials is fed directly to plant quality and process labs to inform future production adjustments.
Each shipment is backed by batch history, including raw material lot traceability, in-process control points, and custom COA data when required. Long-term customers have access to ongoing analytical services to verify identity and performance in end-use settings. If application issues arise post-shipment, immediate escalation paths connect customers to appropriate manufacturing and analytical staff for resolution, including support for root cause analysis when feed or formulation performance deviates from expectations.
Industrial sectors have raised the standards for raw materials, especially for specialty derivatives like L-Ascorbate-2-Phosphate. Our production focuses on meeting these requirements through a direct, controlled, factory-based approach.
At our manufacturing facility, all steps from synthesis, crystallization, filtration, and drying happen on-site under controlled conditions. Teams oversee every batch, tracking raw material usage, process parameters, and critical quality checkpoints. Maintaining direct control eliminates the variability seen with fragmented supply chains and brings confidence to downstream users.
L-Ascorbate-2-Phosphate has earned its place in industries that demand stable forms of vitamin C, such as animal nutrition, aquaculture feeds, cosmetics, and some pharmaceutical preparations. Feed compounders select it for high-temperature extrusion processes where regular ascorbic acid degrades. Cosmetic and topical formulation developers appreciate the molecule's slow oxidation profile during storage. Wherever extended shelf life, process robustness, and consistent dosing matter, this derivative continues to meet the mark.
Maintaining predictable performance starts with raw material traceability. Through in-line process analytics, batch retention sampling, and regular equipment calibration, we systematically cut variation. Post-production, each lot passes through a series of verification tests using validated HPLC methods and impurity profiling. Retained reference samples allow for trace-back and continuous improvement. Industrial partners can benchmark our typical specifications against delivery samples to see the value in our repeatable control.
Bulk users and formulators have diverse packaging needs. To safeguard ingredient integrity, our packaging lines offer sealed fiber drums with double PE liners, as well as customizable palletization options for larger runs. Warehousing and dispatch operate on a batch-code basis to assist with inventory rotation and traceability audits. As a factory, managing inventory at source gives us flexibility to support regular shipments or large project-based orders without delay or cross-contamination risk.
Process engineers and product developers often require more than a standard product. With our own analytical lab and on-site technical specialists, we provide detailed application advice on everything from blending ratios to downstream processing risk factors. For feed, cosmetic, and specialty chemical uses, our team works directly with client R&D and production teams on technical validations and compliance documentation as needed.
Industrial buyers, procurement managers, and distribution partners have clear metrics for seasonality, sampling, and delivery assurance. Direct factory access brings better lead times, consistent product markers, and controlled lot histories. Being responsible for every step from incoming raw material through packaged product enables open communication, easier troubleshooting, and faster scale-up for new projects. These controls reduce unforeseen interruptions and lower the indirect costs associated with requalification, inconsistent supply, or unexpected specification drift.
L-Ascorbate-2-Phosphate continues to deliver practical value to industries seeking chemical reliability and performance. We sustain this standard through direct management of manufacturing, quality, and logistics. This approach not only supports predictable downstream processing, it builds commercial value at every stage for manufacturers, volume users, and distribution professionals who require a single point of technical and production accountability.
Anyone involved in the food, cosmetics, or animal nutrition industries pays close attention to L-Ascorbate-2-Phosphate’s specifications, and so do we. As direct manufacturers, we know these numbers impact how smoothly a customer’s application or downstream process runs. Molecular weight and purity do not simply matter on paper—they form the basis for precise dosing, compliance, and process design.
L-Ascorbate-2-Phosphate, often used for its stable vitamin C properties, carries a molecular weight of 322.19 g/mol for the monopotassium salt form. This figure comes straight from the compound’s molecular structure. Production teams rely on this figure just as much as customers do, whether calculating concentrations for feed formulations, or when designing buffers for cell culture media. Using a well-known figure for molecular weight avoids errors, supports regulatory filings, and ensures dosing predictability. In our factory, every production batch begins with a stoichiometric calculation based on this molecular weight—no shortcuts.
Purity is too often written off as a checkbox on a certificate. In an operational chemical production environment, purity is a process endpoint, a quality promise, and a customer safeguard. Our L-Ascorbate-2-Phosphate product achieves a minimum purity of 98%, and most lots read higher on fresh analysis. We determine purity using validated methods such as HPLC and titration. Analytical records for every batch stay archived with us, fully traceable. Impurity profiles—including moisture and residual solvents—are monitored at each shift, not simply at the end of a run. For customers formulating specialty animal feeds, tissue culture media, or high-stakes food blends, this high assay means confidence in predictability and reactivity.
Maintaining consistent assay and tightly controlled molecular weight in practice takes well-engineered process controls. Our purification stage retains antioxidant properties while removing process impurities without decomposing the phosphate group or the ascorbate core. Staff in our QA lab see every batch prior to packaging and shipping. Stability checks, shelf life studies, and retention sample archiving are part of the daily routine. Deviation reports—if anything drifts even by half a percent—kick off internal reviews and do not leave us wondering what might have gone wrong.
End users approach the L-Ascorbate-2-Phosphate market with higher and changing expectations for documentation, transparency, and predictable supply. We match this by supplying batch-level certificates, real-time tracking of analytical results, and, for qualified partners, access to our detailed methods and regulatory dossiers. Whenever special purity or packaging needs surface, our technical team works directly with the customer, not through layers of distribution. Immediate, factory-direct conversation keeps complex problems simple: assay optimization, impurity troubleshooting, or blending into precise powder form all see fast turnarounds due to our in-house technical staff and vertical integration from synthesis to delivery.
Our approach is built on responsiveness and accountability. We produce, analyze, and package every lot internally. Customers avoid the uncertainty and delays that come from third-party supply chains. Every specification we publish is sourced from our in-house manufacturing records—not marketing brochures or traders’ documentation. Any change in upstream ingredient source, raw material, or process parameter gets communicated through a responsible, documented process. For organizations seeking absolute clarity on L-Ascorbate-2-Phosphate’s molecular weight or purity, factory-direct engagement delivers answers; the numbers do not change between the lab and the label.
Producing L-Ascorbate-2-Phosphate at scale brings insights that only hard-won plant experience can shape. Handling and storage isn’t just a formality—it shapes both cost and quality from the start. We have settled on packaging that aligns with both regulatory safety and plant handling realities. Commonly, we fill 25 kg fiber drums lined with polyethylene. These drums remain robust during transit and perform well against moisture or contamination risks. We fill and seal each lot on automated lines, minimizing human contact and potential for mix-ups. Our technicians regularly review whether drum, carton, or bag could serve better for custom requests, but 25 kg remains the baseline due to efficiency in filling, movement on pallets, and downstream blending in end-use facilities.
Factories running cost-sensitive operations rely on predictable logistics above all. For regular bulk orders—defined as full pallet lots or higher—we maintain scheduled capacity in our monthly production plan. In most cases, standard orders ship within three weeks of confirmation. Volume spikes, seasonal surges, or customer specifications around particle size or packaging material sometimes call for a few days’ adjustment, but our production team actively monitors both raw material and finished product inventory to keep delays at bay.
Any request exceeding one metric ton generally enters a committed contract slot, which helps us secure raw input early and plan continuous output without disrupting quality standards. Strategic reserves of finished product buffer against supply fluctuation, especially for larger food, feed, and cosmetic industry contracts where offtake rates rarely match week-to-week. Our logistics staff manages documentation, customs paperwork, and packing list accuracy in-house as well, shortening the step between production close and truck or container loading.
Some customers run small formulations or test runs and need tailored batch sizes. Our plant can accommodate 10 kg, 20 kg, and 50 kg options where genuine operational need exists, though 25 kg drums remain the flagship format for international movement and safe stacking in warehouses. To reduce warehouse crowding or support just-in-time production, we schedule drop-shipments, multi-location dispatches, or split pallet lots upon request. These arrangements rely on clear forecasts and pre-agreed packing formats, streamlining both paperwork and physical handling at the delivery point.
The challenge emerges most acutely during audit season or regulatory re-inspection, when partner labs and quality teams suddenly require batch records, stability results, or extra documentation on drum materials. Our technical team responds without outsourcing—drawing on years of production logs, in-process controls, and retained samples to close out queries with facts rather than speculation.
The global market for L-Ascorbate-2-Phosphate responds quickly to economic or policy changes. While some industrial buyers take spot quantities opportunistically, we maintain a steady manufacturing rhythm tied to multi-year repeat contracts. That approach means customers receive not only competitive terms but also peace of mind on shipment timetables and repeat consistency from drum to drum. Keeping lines of communication open on forecasts and packaging preference—well before the next order is due—remains the surest way to avoid disruption on both sides of the partnership.
Manufacturing L-Ascorbate-2-Phosphate brings a unique set of regulatory and handling questions, especially as markets worldwide become more conscious of supply chain transparency. Compliance with international standards such as REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals) stands for more than a check-the-box exercise. Our REACH compliance reflects the way we manage risk, prioritize worker safety, and protect the end user.
In the chemical manufacturing field, nothing slows down business like compliance uncertainty. We register our L-Ascorbate-2-Phosphate for REACH before distributing within the European Economic Area. This doesn’t just fulfill a legal obligation—it protects downstream users and keeps goods moving across borders. Our product dossier details intrinsic properties, production volumes, and intended uses. Meeting the European Chemical Agency’s requirements allows our clients freedom to formulate, sell, and transport without disruption.
Documenting production routes and consistent impurity profiles often consumes significant resources. Still, we see this as essential for maintaining trust and enabling audits when needed. Our technical staff invest time in maintaining data on purity and hazard classification; all technical documentation tying into each batch gets archived and can be provided for regulatory audit at a moment’s notice.
Our experience transporting L-Ascorbate-2-Phosphate to both domestic and export markets has taught us the value of clear, complete shipping paperwork. The classification of this material in accordance with the Globally Harmonized System (GHS) informs our safety data sheet, incorporated with every shipment. In our process, every consignment leaves our factory accompanied by a Safety Data Sheet and Certificate of Analysis. These documents reference the correct batch number, hazard symbol, and storage guidance, so handlers and customs officials recognize compliance from the outset.
On the shipping floor, our packaging methods are designed not just to avoid damage but to meet international safety codes. The product does not exhibit explosive or highly flammable behavior, but our documentation covers the possibility of dust formation. This matters for end users incorporating L-Ascorbate-2-Phosphate into food, feed, or cosmetics—our technical team remains available to support with route-specific paperwork such as Transport Emergency Cards or customs declarations, should regulatory agencies require them.
Issues arise if documentation fails to keep up with regulatory changes, which we see regularly in the chemical sector. Our regulatory team monitors updates from the European Chemicals Agency and local authorities, adjusting our compliance strategy as necessary. We update customers if changes in hazard classification demand new labeling or revisions to the SDS.
We address questions about origin, traceability, or export license in-house without delay. Our commitment means we won’t ship product without full documentation ready for inspection—not only to ensure compliance but to reduce customs holdups for our clients. Firms that take shortcuts with REACH or documentation do so at the risk of delayed shipments and potential fines. We choose to adhere to a higher standard, both for regulatory approval and for the confidence it provides to our partners.
Every shipment of our L-Ascorbate-2-Phosphate leaves our site fully documented and compliant, eliminating surprises down the line and setting a benchmark for what manufacturers can deliver.For product inquiries, sample requests, quotations or after-sales support, please feel free to contact me directly via sales7@bouling-chem.com, +8615371019725 or WhatsApp: +8615371019725
